{2-[(tert-butoxycarbonyl)amino]pyridin-3-yl}boronic acid is an organic compound with the chemical formula C12H17BN2O4.
Its properties are as follows:
-Appearance: White crystalline powder.
-Melting point: about 211-214°C.
-Solubility: Soluble in some organic solvents, such as methanol, dimethyl sulfoxide, chloroform, etc.
{2-[(tert-butoxycarbonyl)amino]pyridin-3-yl}boronic acid has a wide range of applications:
-As an important intermediate in organic synthesis, it is used to synthesize various nitrogen-containing organic compounds.
-can be used to synthesize drugs, pesticides and other active molecules.
-In coordination chemistry, it can be used as a ligand to participate in the preparation and reaction of metal organic compounds.
Preparation Method:
{2-[(tert-butoxycarbonyl)amino]pyridin-3-yl}boronic acid can be synthesized by the following steps:
1. 2-Chloropyridine is reacted with N-tert-butoxycarbonylaminosilane to obtain 2-(tert-butoxycarbonylamino) pyridine.
2. React 2-(tert-butoxycarbonylamino) pyridine with triphenylboron to obtain the final product {2-[(tert-butoxycarbonyl)amino]pyridin-3-yl}boronic acid.
Safety Information:
- {2-[(tert-butoxycarbonyl)amino]pyridin-3-yl}boronic acid may be irritating to skin, eyes and respiratory system. Wear protective equipment to avoid contact.
-Avoid inhaling dust and vapor from the solution, and ensure that it is operated in a well-ventilated place.
-Storage should be sealed to avoid contact with oxidants and acidic substances.